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Anxiety

Signs, symptoms and indicators | Conditions that suggest it | Contributing risk factors | Other conditions that may be present | Treatment recommendations
 

Anxiety can be an appropriate or inappropriate response to threats of many types. An appropriate response would be to become anxious regarding threatening circumstances (physical, emotional, financial threats). In this case, taking immediate action to reduce the threat would be appropriate. If the threat is going to be prolonged and can not be changed, then how the threat is viewed must be changed to reduce the likely mental and health consequences. At times, fear and anxiety can get out of hand, inexplicably reaching overwhelming levels. In these cases, anxiety can result in a dramatic reduction of productivity and can significantly intrude on one's quality of life. Often, there is no obvious or reasonable cause for the anxiety. Some common symptoms of anxiety include the following:

  • A tense, uptight feeling
  • Inability to relax
  • Feeling restless, keyed up, or on edge
  • Muscle tension, aches, or soreness
  • Trouble falling or staying asleep
  • Difficulties concentrating
  • Irritability or impatience
  • Physical symptoms such as sweaty palms, heart palpitations, shortness of breath, nausea or diarrhea, and trouble swallowing.
Anxiety commonly results from chronic stress. Mental health professionals speak of "anxiety disorders", of which there are multiple types - Generalized Anxiety Disorder, Panic Disorder, Obsessive-compulsive Disorder, Post-traumatic Stress Disorder - to mention but a few. In addition to anxiety, other psychological or physical symptoms can be experienced.

Psychological symptoms associated with anxiety may include overwhelming worry, apprehension, nervousness and a nagging uneasiness about the future. Physical symptoms can include rapid heartbeat and palpitations, sweating, dizziness, headaches, insomnia and relentless fatigue. The set of symptoms that an individual experiences helps physicians diagnose their specific disorder. Anxiety disorders, like depression, may run in families and be linked to an imbalance in neurotransmitters. Anxiety symptoms are often relieved when the depression is successfully treated.

If anxiety is disproportional to life's circumstances and there are no obvious underlying reasons for the it, psychological and biochemical disturbances should be investigated. Alternative medicine has a lot to offer in this respect, common recommendations including avoiding caffeine, sugar and alcohol. Hidden food allergies may be a contributing factor or cause.

Nutrients such as calcium and magnesium, B-vitamins, niacinamide, B12 injections (especially if stomach acid production is insufficient), tryptophan with inositol and chromium, valerian root, and GABA can have a calming effect.

Certain foods can worsen anxiety. Dairy products, chocolate, sugar, alcohol, wheat, salt, commercial salad dressings, ketchup (catsup), mustard, coffee, black tea, and red meat may worsen anxiety symptoms. High-nutrient foods such as vegetables, brown rice, whole grains, seeds and nuts, fruits, poultry, fish, olive oil, and flax seeds/oil can help relieve stress and prevent anxiety. If you feel anxious, jittery, depressed or fatigued after eating a particular food, don't eat it.

In people with chronic anxiety unrelated to life events, an injection of sodium lactate will trigger a panic attack. Eating a lot of foods high in refined sugar increases blood lactate levels and can induce panic in susceptible persons. Eliminating caffeine and alcohol and refined sugars from the diet is essential for anyone suffering from anxiety.


Signs, symptoms & indicators of Anxiety:
Symptoms - Mind - Emotional   Being anxious/nervous (confirmed)
  Impatient/hostile disposition
  Feelings of insecurity

Symptoms - Mind - General

  Jumpiness

Symptoms - Nervous

  Facial burning/tingling
  Anxiety conditions can cause adrenaline surges which result in tingling of the face, as well as other parts of the body.

Symptoms - Sleep

  Unsound sleep
  (Frequent) difficulty falling asleep

Conditions that suggest Anxiety:
Circulation   Atherosclerosis
  Researchers conclude that chronically high levels of anxiety are a risk factor for the progression of atherosclerosis, especially in men. [Arterioscler Thromb Vasc Biol 2001; 21: pp.136-141]

Digestion

  IBS (Irritable Bowel Syndrome)
  Constipation
  This connection is discussed in the link between constipation and stress.

Metabolic

  Ayurvedic Dosha - Vata Dominance

Nervous System

  Tremors

Risk factors for Anxiety:
Cell Salts   Kali Phos Cell Salt Need

Environment / Toxicity

  Mercury Toxicity (Amalgam Illness)

Habits

  Lack of Sleep

Hormones

  Hyperthyroidism
  Low Serotonin Level
  Serotonin levels are often low among people with anxiety disorders.

  Progesterone Low or Estrogen Dominance
  Low Adrenal Function / Adrenal Insufficiency
  Adrenal insufficiency can lead to a host of problems, including a weakened immune response, anxiety and panic attacks.

  Low Melatonin Level

Immunity

  Chronic Fatigue / Fibromyalgia Syndrome
  Depression or anxiety may occur as a result of the chronic pain and fatigue, or the frustration felt with this condition. It is also possible that the same chemical imbalances in the brain that cause fibromyalgia also cause depression and anxiety. Some 24% of patients suffer from anxiety.

Infections

  Epstein-Barr virus (EBV)

Mental

  Stress

Metabolic

  Pyroluria
  Pyroluria is a known biochemical marker for life long anxiety symptoms. According to one alcoholism treatment center, one-third to one-half of alcoholics treated have this marker. High levels of pyrrolles systematically bind to B6 and zinc, preventing the use of these nutrients in the body and brain. The result is a myriad of symptoms, including severe inner tension, ongoing anxiety, poor stress control, fearfulness, and sometimes episodic anger.

  Wernicke-Korsakoff syndrome
  Hypoglycemia

Nutrients

  Magnesium Requirement
  Magnesium deficiency causes increased levels of adrenaline, which can lead to a feeling of anxiety.

Supplements and Medications

  (Discontinued) antianxiety drug use

Anxiety suggests the following may be present:
Hormones   Hyperthyroidism

Metabolic

  Wernicke-Korsakoff syndrome

Recommendations and treatments for Anxiety:
Amino Acid / Protein   GABA (gamma-aminobutyric acid)
  GABA has a powerful calming effect on the brain. Tranquilizers like Valium and Librium work by stimulating the brain's receptors for GABA.

  Tryptophan / 5 HTP
  Tryptophan (or 5-HTP), the precursor of the sleep-inducing neurotransmitter serotonin, also has relaxing and calming effects. Serotonin levels are often low among people with anxiety disorders. A recent study found that 44% of alcoholics suffer from anxiety. You can be pretty sure that you are low on tryptophan if you have ever blacked out from drinking. It has been established that low tryptophan stores trigger blackouts.

Botanical

  Valerian Root (Valeriana officinalis)
  Kava
  Kava appears to be as effective as the class of synthetic pharmaceuticals called benzodiazepenes (such as Valium) for treating anxiety, but without their dangerous side-effects of sedation and addiction. Only about 2% of patients taking kava reported minor side-effects, predominantly gastrointestinal complaints, skin reaction, headache and photosensitivity. Other research has shown that kavapyrones act on receptors in the hippocampus and amygdala complexes in the brain to produce measurable changes in brain wave activity and reduce anxieity. [Journal of Clinical Psychopharmacology 2000 Feb;20(1): pp.84-9]

Research has also suggested that anxiety may be related to an increased risk of myocardial infarction and fatal coronary disease. This risk may be due to an impairment of the parasympathetic nervous system with lower vagal control being reported in persons with more severe anxiety. Although preliminary, due to the small sample size, a trial suggests that kava extract (280mg standardized extract per day) may target the baroreceptor pathway and improve Baroreflex control of heart rate (BRC) in patients with generalized anxiety. [J Psychopharmacol 2001;15: pp.283-86] []

  Frankincense (Boswellia carteri)
  Frankincense oil can help to fortify a mind burdened with mental anxiety, nervous tension or stress. It reduces anxiety and helps revitalize the mind when a person is mentally exhausted.

  Passionflower (Passiflora incarnata)
  Treatment with passionflower extract over a one month period compared favorably to oxazepam (Serax - an antianxiety benzodiazepine drug) in a randomized, double-blind study of 36 outpatients diagnosed with generalized anxiety disorder. Passionflower extract demonstrated a slower onset of action and less impairment of job performance than did oxazepam. [J Clin Pharm Ther 2001;26(5): pp.363-7]

Diet

  Sugars Avoidance / Reduction
  Caffeine/Coffee Avoidance
  Caffeine can cause adrenal insufficiency which in turn can lead to anxiety.

  Alcohol Avoidance
  Aspartame (Nutrasweet) Avoidance

Drug

  GHB (Gamma-Hydroxybutyrate)
  GHB’s efficacy for treating anxiety has been positively demonstrated in tests involving schizophrenic subjects [Laborit, 1964]. Its sedative properties have earned it a role as a psychotherapeutic adjunct [Vickers, 1969]. It has also been used to assist the process of “abreaction”, or the release (usually through verbalization) of repressed emotion [Vickers, 1969]. Unlike other “anxiolytic” (or anti-anxiety) drugs, GHB’s effect is non-toxic. Furthermore, GHB’s reduction of inhibitions, its tendency to encourage verbalization, and the typical lack of fear during the GHB experience would seem to provide an ideal context for the verbal exploration of difficult emotional territory during therapy.

Habits

  Aerobic Exercise
  Exercise is one of the most important coping mechanisms to combat anxiety and stress. By discharging negative emotions and stress hormones through physical activity, you can enter a more relaxed state from which to deal with the issues and conflicts that are causing your anxiety.

The benefits of exercise can come from many directions: the decision to take up exercise, the symbolic meaning of the activity, the distraction from worries, mastering your inertia and the effects on self-image, and the biochemical and physiological changes that accompany the activity.

Exercise increases blood flow to the brain, releases hormones, stimulates the nervous system, and increases levels of morphine-like substances found in the body (such as beta-endorphin) that can have a positive effect on mood and pain. Exercise may trigger a neurophysiological high that produces an antidepressant effect in some, an antianxiety effect in others, and a general sense of "feeling better" in most.

Lab Tests/Rule-Outs

  Test for Food Allergies

Mineral

  Calcium
  Magnesium
  Because of its nerve and muscle support, magnesium may also be helpful for nervousness and anxiety. Magnesium is considered the "antistress" mineral. It is a natural tranquilizer as it functions to relax skeletal muscles as well as the smooth muscles of blood vessels and the gastrointestinal tract. Whereas calcium stimulates muscle contraction, magnesium relaxes them.

Nutrient

  DMAE
  DMAE alleviates anxiety. In one study, subjects administered 1,200mg of DMAE per day for 5 days exhibited better control of anxious reactivity.

  Meyer's Cocktail
  Inositol
  Inositol works by regulating the action of serotonin, a calming neurotransmitter, within the nerve cells.

Psychological

  Counseling

Vitamins

  Vitamin B-Complex
  Several of the B-vitamins are indicated in anxiety treatment. When taking high doses of a particular B-vitamin, it is best to use a B-complex as well.

  Vitamin Niacinamide
  The textbook description of anxiety neurosis exactly matches the symptoms of vitamin B3 (niacin) deficiency: hyperactivity, depression, fatigue, apprehension, headache, and insomnia. It has been shown in animals to work in the brain in ways similar to drugs such as benzodiazepines (Valium-type drugs) that are used to treat anxiety. One study found that niacinamide (not niacin) could help people get through withdrawal from benzodiazepines, which is a common problem. A reasonable amount of niacinamide to take for anxiety, according to some doctors, is up to 500mg four times per day.

Niacinamide locks onto the same receptor sites in the brain as do tranquilizers such as Valium, and is a natural tranquilizer. The manufacturer of valium is also the worlds largest manufacturer of niacinamide. [Nature 278: pp.563-5,1979]

  Vitamin B12 (Cobalamine)
  Low B12 levels have been found to be related to self-reported overall distress level and specifically to depression, anxiety, confusion, and possibly nervousness as well as to clinically rated depressed and anxious mood. [J Psychosom Res 2000 Feb 1; 48(2): pp.177-85]

  Vitamin B6 (Pyridoxine)
  A deficiency of vitamin B6 (pyridoxine) causes extreme anxiety, nervousness, confusion, and melancholy. Vitamin B6 is easily destroyed by heavy use of alcohol, drugs and refined sugars.


KEY
Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
May do some good
Likely to help
Highly recommended


GLOSSARY

Adrenal Insufficiency (Adrenal Exhaustion, Low Adrenal Function)
A condition in which the adrenal gland is compromised in its production of epinephrine, norepinephrine, cortisol, corticosterone or aldosterone. Symptoms include primarily fatigue, weakness, decreased appetite with ensuing weight loss, as well as nausea, vomiting, abdominal pain, diarrhea or constipation, or increased pigmentation of the skin. Cortical insufficiency (low or no corticosteroids) produces a more serious condition called Addison’s Disease, characterized by extreme weakness, low blood pressure, pigmentation of the skin, shock or even death.

Adrenaline (Epinephrin, Epinephrine)
A hormone secreted by the adrenal medulla that is released into the bloodstream in response to physical or mental stress, as from fear or injury. It initiates many bodily responses, including the stimulation of heart action and an increase in blood pressure, metabolic rate, and blood glucose concentration.

Allergy (Allergies)
Hypersensitivity caused by exposure to a particular antigen (allergen), resulting in an increased reactivity to that antigen on subsequent exposure, sometimes with harmful immunologic consequences.

Anxiety
Apprehension of danger, or dread, accompanied by nervous restlessness, tension, increased heart rate, and shortness of breath unrelated to a clearly identifiable stimulus.

Atherosclerosis
Common form of arteriosclerosis associated with the formation of atheromas which are deposits of yellow plaques containing cholesterol, lipids, and lipophages within the intima and inner media of arteries. This results in a narrowing of the arteries, which reduces the blood and oxygen flow to the heart and brain as well as to other parts of the body and can lead to a heart attack, stroke, or loss of function or gangrene of other tissues.

Calcium
The body's most abundant mineral. Its primary function is to help build and maintain bones and teeth. The body also needs calcium to carry nerve signals, keep the heart functioning, contract muscles, clot blood and maintain healthy skin. Calcium helps control blood acid-alkaline balance, plays a role in cell division, muscle growth and iron utilization, activates certain enzymes, and helps transport nutrients through cell membranes. Calcium also forms a cellular cement called ground substance that helps hold cells and tissues together.

Chromium
Chromium is a mineral that becomes a part of the glucose tolerance factor (GTF). Chromium aids in insulin utilization and blood sugar control. By controlling blood sugar, chromium helps prevent the damage caused by glucose, which is called glycation. Chromium helps maintain normal cholesterol levels and improves high-density lipoprotein levels. Chromium is also important in building muscle and reducing obesity.

Chronic (Chronicity)
Usually referring to chronic illness: Illness extending over a long period of time.

Cobalamin (B12, B-12, Cobalamine, Vitamin B12)
Essential for normal growth and functioning of all body cells, especially those of bone marrow (red blood cell formation), gastrointestinal tract and nervous system, it prevents pernicious anemia and plays a crucial part in the reproduction of every cell of the body i.e. synthesis of genetic material (DNA).

Constipation (Constipated)
Difficult, incomplete, or infrequent evacuation of dry, hardened feces from the bowels.

Diarrhea
Excessive discharge of contents of bowel.

Fibromyalgia (FMS)
Originally named fibrositis, it is a mysteriously debilitating syndrome that attacks women more often than men. It is not physically damaging to the body in any way, but is characterized by the constant presence of widespread pain that often moves about the body. Fibromyalgia can be so severe that it is often incapacitating.

Flax (Flax Oil, Flax Seed)
Flax Seed or Flax Oil. Flax oil is nutty-flavored oil that is pressed out of flax seeds and is one of the richest sources of Essential Fatty Acids (EFAs), a vital element for good health. The oil making process removes many of the seed's phytoestrogens which offer several health-related benefits including reducing the risk of cancer and alleviating menopausal symptoms. Many choose to use the whole seed because of its fiber and lignan content. Flaxseed oil is light- and temperature-sensitive and must be stored in the refrigerator.

Gamma-Aminobutyric Acid (GABA)
An amino acid derivative that is a calming substance. Tranquilizers such as valium and Librium owe their soothing effects to the fact that they stimulate GABA receptors in the brain.

Gastrointestinal (GI, GI Tract)
Pertaining to the stomach, small and large intestines, colon, rectum, liver, pancreas, and gallbladder.

Hippocampus
Brain structure that forms the edge of the cortical mantle of the cerebral hemisphere.

Hormones (Hormone)
Chemical substances secreted by a variety of body organs that are carried by the bloodstream and usually influence cells some distance from the source of production. Hormones signal certain enzymes to perform their functions and, in this way, regulate such body functions as blood sugar levels, insulin levels, the menstrual cycle, and growth. These can be prescription, over-the-counter, synthetic or natural agents. Examples include adrenal hormones such as corticosteroids and aldosterone; glucagon, growth hormone, insulin, testosterone, estrogens, progestins, progesterone, DHEA, melatonin, and thyroid hormones such as thyroxine and calcitonin.

Inositol
Usually considered part of the vitamin B complex. It is thought that along with choline, inositol is necessary for the formation of lecithin within the body. Involved in calcium mobilization.

Lactation (Lactate, Lactates, Lactating)
Production of milk; period after giving birth during which milk is secreted in the breasts.

Magnesium
An essential mineral. The chief function of magnesium is to activate certain enzymes, especially those related to carbohydrate metabolism. Another role is to maintain the electrical potential across nerve and muscle membranes. It is essential for proper heartbeat and nerve transmission. Magnesium controls many cellular functions. It is involved in protein formation, DNA production and function and in the storage and release of energy in ATP. Magnesium is closely related to calcium and phosphorus in body function. The average adult body contains approximately one ounce of magnesium. It is the fifth mineral in abundance within the body--behind calcium, phosphorus, potassium and sodium. Although about 70 percent of the body's magnesium is contained in the teeth and bones, its most important functions are carried out by the remainder which is present in the cells of the soft tissues and in the fluid surrounding those cells.

Milligram (mg, Milligrams)
0.001 or a thousandth of a gram.

Mineral (Minerals)
Plays a vital role in regulating many body functions. They act as catalysts in nerve response, muscle contraction and the metabolism of nutrients in foods. They regulate electrolyte balance and hormonal production, and they strengthen skeletal structures.

Nausea
Symptoms resulting from an inclination to vomit.

Nervous System
A system in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that receive and interpret stimuli and transmit impulses to effector organs.

Neurotransmitters (Neurotransmitter)
Chemicals in the brain that aid in the transmission of nerve impulses. Various Neurotransmitters are responsible for different functions including controlling mood and muscle movement and inhibiting or causing the sensation of pain.

Niacin (B3, B-3, Niacinamide, Vitamin B3)
A coenzyme B-complex vitamin that assists in the breakdown of carbohydrates, fats and proteins. Essential for the health of the skin, nerves, tongue and digestive system. It is found in every cell of the body and is necessary for energy production. Niacin is also needed for DNA formation.

Obsessive-Compulsive Disorder (Obsessive-Compulsive, OCD)
Those suffering from OCD have obsessions and/or compulsions. Obsessions refer to recurrent and persistent thoughts, impulses, or images that are intrusive and cause severe anxiety or distress. Compulsions refer to repetitive behaviors and rituals (such as hand washing, hoarding, ordering, checking) or mental acts (like counting, repeating words silently, avoiding). These obsessions and compulsions significantly interfere with normal routine, functioning, social activities and relationships.

Panic Attack (Panic Attacks)
A brief, irrational episode of fear that is perceived as so real that an individual may be driven to escape from the place or situation where it occurs. The attack is sudden and increases in severity until it leaves, usually within ten minutes. Panic attack symptoms are numerous and involve both mental and physical signs and symptoms. A panic attack can occur in other anxiety states such as agoraphobia and with certain activities and places. It may occur spontaneously without an apparent cause.

Panic Disorder
A condition whereby an affected individual has recurrent and unexpected panic attacks and worries a great deal of the time about having another. The individual may also have persistent concern or fear that a panic attack might cause unrelated health problems or a demonstrable change in usual behavior. The symptoms of panic disorder must be present for at least one month to confirm the diagnosis.

Parasympathetic
Usually Parasympathetic nervous system: Portion of the autonomic nervous system that is generally associated with increasing digestion and intestinal muscle activity; decreasing blood circulation and respiration.

Precursor (Precursors)
A biochemical substance, such as an intermediate compound in a chain of enzymatic reactions, from which a more stable or definitive product is formed.

Pyridoxine
A B-complex vitamin that plays a role as a coenzyme in the breakdown and utilization of carbohydrates, fats and proteins. It facilitates the release of glycogen for energy from the liver and muscles. It also participates in the utilization of energy in the brain and nervous tissue and is essential for the regulation of the central nervous system.

Pyroluria
This condition is caused by an overproduction during hemoglobin synthesis of kryptopyrrole, which chemically combines with vitamin B6 and zinc, resulting in their excretion and a severe deficiency of both of these essential nutrients. Most pyroluric individuals never develop
schizophrenia symptoms.

Refined Sugar (Refined Sugars)
The term 'refined sugar' includes not only the “sugar” listed in ingredient listings, but also brown sugar, glucose, fructose and dextrose. Obvious sources include jams and jellies; hidden sources are often mayonnaise, ketchup, salad dressings and other condiments.

Sedative
Calming, quieting; drug that quiets nervous excitement.

Serotonin
A phenolic amine neurotransmitter (C10H12N2O) that is a powerful vasoconstrictor and is found especially in the brain, blood serum and gastric membranes of mammals. Considered essential for relaxation, sleep, and concentration.

Sodium
An essential mineral that our bodies regulate and conserve. Excess sodium retention increases the fluid volume (edema) and low sodium leads to less fluid and relative dehydration. The adult body averages a total content of over 100 grams of sodium, of which a surprising one-third is in bone. A small amount of sodium does get into cell interiors, but this represents only about ten percent of the body content. The remaining 57 percent or so of the body sodium content is in the fluid immediately surrounding the cells, where it is the major cation (positive ion). The role of sodium in the extracellular fluid is maintaining osmotic equilibrium (the proper difference in ions dissolved in the fluids inside and outside the cell) and extracellular fluid volume. Sodium is also involved in nerve impulse transmission, muscle tone and nutrient transport. All of these functions are interrelated with potassium.

Stomach
A hollow, muscular, J-shaped pouch located in the upper part of the abdomen to the left of the midline. The upper end (fundus) is large and dome-shaped; the area just below the fundus is called the body of the stomach. The fundus and the body are often referred to as the cardiac portion of the stomach. The lower (pyloric) portion curves downward and to the right and includes the antrum and the pylorus. The function of the stomach is to begin digestion by physically breaking down food received from the esophagus. The tissues of the stomach wall are composed of three types of muscle fibers: circular, longitudinal and oblique. These fibers create structural elasticity and contractibility, both of which are needed for digestion. The stomach mucosa contains cells which secrete hydrochloric acid and this in turn activates the other gastric enzymes pepsin and rennin. To protect itself from being destroyed by its own enzymes, the stomach’s mucous lining must constantly regenerate itself.

Tryptophan
Essential amino acid. Natural relaxant and sleep aid due to its precursor role in serotonin (a neurotransmitter) synthesis. Along with tyrosine, it is used in the treatment of addictions.

Vitamin B6 (B6, B-6)
Influences many body functions including regulating blood glucose levels, manufacturing hemoglobin and aiding the utilization of protein, carbohydrates and fats. It also aids in the function of the nervous system.

Zinc
An essential trace mineral. The functions of zinc are enzymatic. There are over 70 metalloenzymes known to require zinc for their functions. The main biochemicals in which zinc has been found to be necessary include: enzymes and enzymatic function, protein synthesis and carbohydrate metabolism. Zinc is a constituent of insulin and male reproductive fluid. Zinc is necessary for the proper metabolism of alcohol, to get rid of the lactic acid that builds up in working muscles and to transfer it to the lungs. Zinc is involved in the health of the immune system, assists vitamin A utilization and is involved in the formation of bone and teeth.




Last updated: Jan 15, 2006


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